Coagulation abnormality in the acute phase of trauma: acute traumatic coagulopathy and trauma-induced coagulopathy
نویسندگان
چکیده
منابع مشابه
Acute traumatic coagulopathy and trauma-induced coagulopathy: an overview
Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. Previously, traumatologists and investigators identified iatrogenic and resuscitation-associated causes of coagulopathic bleeding after traumatic injury, including hypothermia, metabolic acidosis, and dilutional coagulopathy that were recognized as primary drivers of bleeding after trauma. However,...
متن کاملAcute Traumatic Coagulopathy: an Endogenous Precursor of Trauma-induced Coagulopathy
Recent findings Trauma causes an acute disruption of the equilibrium between all components of haemostasis (coagulation, anticoagulation, fibrinolysis, platelets and endothelium). In patients with a combination of severe tissue damage and systemic hypoperfusion, this will progress rapidly to an endogenous coagulopathy that is independently associated with worse outcomes. New discoveries of the ...
متن کاملAcute coagulopathy of trauma in the rat.
INTRODUCTION Acute coagulopathy of trauma (aCOT) is a state of disordered coagulation developing soon after severe injury and blood loss and has been defined in the clinical literature as an elevation in prothrombin time (PT) and activated partial thromboplastin time (aPTT). OBJECTIVE The purpose of this study was to develop a rat model of aCOT resulting from polytrauma and hemorrhage and sho...
متن کاملNoble-Collip Drum Trauma Induces Disseminated Intravascular Coagulation But Not Acute Coagulopathy of Trauma-Shock.
BACKGROUND There are two opposing possibilities for the main pathogenesis of trauma-induced coagulopathy: an acute coagulopathy of trauma shock and disseminated intravascular coagulation with the fibrinolytic phenotype. OBJECTIVE The objective of this study was to clarify the main pathogenesis of trauma-induced coagulopathy using a rat model of Noble-Collip drum trauma. METHODS Eighteen rat...
متن کاملDisseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
INTRODUCTION It is debated whether early trauma-induced coagulopathy (TIC) in severely injured patients reflects disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype, acute coagulopathy of trauma shock (ACoTS) or yet other entities. This study investigated the prevalence of overt DIC and ACoTS in trauma patients and characterized these conditions based on their biomarker p...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2016
ISSN: 0915-7441,1880-8808
DOI: 10.2491/jjsth.27.399